Our experts can assist you in all stages of protein crystallization process development – starting from the determination of crystallization conditions, through process design, optimization and scale-up, hardware construction and manufacturing to process integration.

We provide:

• efficient high-throughput methods for the screening of suitable crystallization conditions in vapor diffusion and batch;
• careful biochemical monitoring of the state of the protein before, during and after the crystallization process.

We are able to develop robust procedures for up-streamprocessing
using;

• mapping phase diagrams;
• optimization of stirred processes with a minimal amount of protein, starting from the 2 ml scale;
• online analytic methods;
• sophisticated mathematical methods.

We have profound expertise in construction and hardware manufacturing for pharmaceutical applications and also provide support for production process integration.