Bioprocess Engineering
Electrophysiology for Drug Discovery Research
Our service ...
We offer a range of modern in vitro methods for the investigation of membrane-bound receptors as drug development targets:
- expression and characterization of ion channels and receptors in Xenopus oocytes;
- automated substance testing using the ROBOOCYTE workstation developed in-house;
- secondary testing of hits from high-throughput screening;
- patch clamp measurements on cultured cells, cell lines and primary cultures;
- combination of fluorescence and patch clamp measurements;
- parallel recording with multi-electrode arrays (MEA);
- development and optimization of measuring instruments;
- consulting services and training of customers.
We have broad experience with a wide variety of electrophysiological methods, electrogenic drug targets and test compounds.
Our specific expertise and scientific publications cover nicotinic acetylcholine receptors, chimeric receptors, and the characterization of receptor subtypes.
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